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Life sciences and clinical instrumentation

LaVision BioTec's latest light sheet
microscope, the UltraMicroscope II

LaVision BioTec, developers of advanced microscopy solutions for the life sciences, demonstrated their latest light sheet microscope, the UltraMicroscope II, at the analytica 2016 meeting in Munich.

Light sheet microscopes are being used widely in wide applications areas: from neuroscience and immunology to cancer research and physiology.

The new UltraMicroscope utilizes six thin light sheets to excite samples while the fluorescence light is detected with a sCMOS equipped microscope that is mounted perpendicular to the plane illumination. The microscope combines macro-imaging capabilities with cellular resolution and allows 3D imaging of cleared samples in aqueous and organic buffers. The UltraMicroscope II provides the perfect complementary microscopic technique to macro in vivo techniques such as Bioluminescence Imaging (BLI), Single Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI). Moving the sample through the light sheet generates a 3D image stack. Selective excitation of the focal plane reduces bleaching and photo toxicity significantly. The open setup allows the analysis of cleared samples in any clearing solution or in aqueous media. The dynamic horizontal light sheet focus guarantees excellent Z-resolution covering the entire field of view.

LaVision BioTec also showed their TriM Scope II 2-Photon Microscope. Two-photon excitation microscopy is a fluorescence imaging technique that allows imaging of living tissue up to about one millimeter in depth. Being a special variant of the multiphoton fluorescence microscope, it uses red-shifted excitation light which can also excite fluorescent dyes. Visitors may see examples of the stunning images generated by these microscopes while hearing about the research papers from major laboratories from around the world.

For further information about LaVision BioTec's TriM Scope 2-photon Microscope II and the UltraMicroscope II, view website: www.lavisionbiotec.com   

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