The Journal of Industry and Technology

Industrial Analytical Instrumentation

Euro Technology

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Materials and biophysical characterization technology

Malvern releases new guidance on the use
of automated imaging for agglomerate detection

Malvern Instruments offer guidance on using automated image analysis to detect and quantify agglomerates. The ability of uncontrolled agglomeration to substantially impact the performance and value of powder products makes efficient agglomerate detection vital across a number of industries. 'Identification of agglomerates using automated image analysis' presents practical strategies for efficiently and robustly differentiating agglomerates from primary particles, to support product development, QC and process troubleshooting.

To view the application note, view website:

Agglomerates are formed through the adhesion or cohesion of smaller primary particles. They can have serious implications for product performance, value and, in the case of pharmaceutical products, safety. Any tendency towards agglomeration must therefore be thoroughly investigated during product development, controlled during manufacture and checked in final product QC.

Automated imaging is a fast and efficient technique for studying the morphological characteristics of particulate materials. The new guidance shows how the combination of size and shape data can be used to securely classify particles as agglomerates, enabling the amount of agglomerated material present in a blend to be quantified. In particular, shape parameters such as particle convexity and circularity are shown to be important in differentiating primary particles and agglomerates.

Malvern's Sysmex FPIA 3000 and Morphologi G3 image analysis-based particle characterization systems employ advanced optics to record and analyze images of thousands of particles within suspensions, emulsions and dry powders in a matter of minutes. The Morphologi G3-ID extends the capabilities of image analysis by applying the technique of Morphologically Directed Raman Spectroscopy to enable the chemical identification of multi-component agglomerates that cannot be reliably classified on the basis of size and shape alone. Together, these automated imaging systems provide an efficient solution for robust agglomeration detection.

To find out more about Malvern's advanced particle characterization systems, view website:

Malvern, Malvern Instruments and Morphologi are registered trademarks of Malvern Instruments Ltd .

Malvern Instruments in profile
Malvern provides the materials and biophysical characterization technology and expertise that enables scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern's materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.
Malvern's products reflect its drive to exploit the latest technological innovations and their commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.
Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, nanoparticle size and count, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, Mexico, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

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